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The FER1L4 in melanoma cell lines and in TCGA patients: A) Expression levels in HEMn and <t>HEMa</t> <t>melanocytes</t> and melanoma cell lines depending on the cell type, cell line and BRAF status: BRAF WT (MEVO), BRAF V600E (SKMEL28, WM9 and A549) and BRAF V600D (WM115 and WM266) and B) Expression levels in melanoma patients from TCGA database depending on: primary or distant metastases samples and regional nodal metastases status and BRAF mutation status. Correlation of expression levels between BRAF and the FER1L4 in melanoma BRAF wild type (WT), BRAF mutated (MUT) and BRAF V600E (c. 1799T>A) subgroups; Graphs for metastasis status were taken from UALCAN database, modified; T- test or One way ANOVA with Kruskal-Wallis test, Spearman correlation test, p < 0.05 considered as significant; ns - no significant, * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001
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The FER1L4 in melanoma cell lines and in TCGA patients: A) Expression levels in HEMn and HEMa melanocytes and melanoma cell lines depending on the cell type, cell line and BRAF status: BRAF WT (MEVO), BRAF V600E (SKMEL28, WM9 and A549) and BRAF V600D (WM115 and WM266) and B) Expression levels in melanoma patients from TCGA database depending on: primary or distant metastases samples and regional nodal metastases status and BRAF mutation status. Correlation of expression levels between BRAF and the FER1L4 in melanoma BRAF wild type (WT), BRAF mutated (MUT) and BRAF V600E (c. 1799T>A) subgroups; Graphs for metastasis status were taken from UALCAN database, modified; T- test or One way ANOVA with Kruskal-Wallis test, Spearman correlation test, p < 0.05 considered as significant; ns - no significant, * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001

Journal: EXCLI Journal

Article Title: Fer-1 like family member 4 pseudogene: novel potential diagnostic and prognostic biomarker for cutaneous melanoma

doi: 10.17179/excli2024-7719

Figure Lengend Snippet: The FER1L4 in melanoma cell lines and in TCGA patients: A) Expression levels in HEMn and HEMa melanocytes and melanoma cell lines depending on the cell type, cell line and BRAF status: BRAF WT (MEVO), BRAF V600E (SKMEL28, WM9 and A549) and BRAF V600D (WM115 and WM266) and B) Expression levels in melanoma patients from TCGA database depending on: primary or distant metastases samples and regional nodal metastases status and BRAF mutation status. Correlation of expression levels between BRAF and the FER1L4 in melanoma BRAF wild type (WT), BRAF mutated (MUT) and BRAF V600E (c. 1799T>A) subgroups; Graphs for metastasis status were taken from UALCAN database, modified; T- test or One way ANOVA with Kruskal-Wallis test, Spearman correlation test, p < 0.05 considered as significant; ns - no significant, * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001

Article Snippet: Human adult and neonatal primary epidermal melanocytes HEMa (ATCC® PCS-200-013) andHEMn (ATCC® PCS-200-012), respectively, and human melanoma cell lines MEWO, SKMEL28, WM115, WM266, WM9, and A549 were used for the study.

Techniques: Expressing, Mutagenesis, Modification